Transfer Factor (diffusing capacity) for nitric oxide (TLNO/DLNO)
Reviews, editorials
Borland Colin DR, Hughes Mike. Transfer factor (Tl) for carbon monoxide and (CO) and nitric oxide (NO). In: Cotes’s Lung Function, 7th edition. RL Maynard, SJ Pearce, B Nemery, PD Wagner, BG Cooper (eds). WILEY Blackwell. 2020. Chapter 18, 313-352.
Borland Colin DR, Hughes J Mike B. Lung diffusing capacities (DL) for nitric oxide (NO) and carbon monoxide (CO): the evolving story. Compr Physiol 2020; 10: 73-97.
Zavorsky GS, Hsia CC, Hughes JM, Borland CD, Guénard H, Van Der Lee I, Steenbruggen I, Naeije R, Cao J, Dinh-Xuan AT. Standardisation and application of the single-breath determination of nitric oxide. Eur Respir J 2017; 49(2): 1600962.
Zavorsky GS, Hsia CC, Hughes JMB, Borland CD, Guénard H, van der LeeI, Steenbruggen I, Naeije R, Cao J, Dinh-Xuan AT. Standardisation and application of the single-breath determination of nitric oxide uptake n the lung Eur Respir J. 2017 Feb 8; 49(2): 1600962. Download
Hughes JMB, Dinh-Xuan AT. The TL,NO/TL,CO ratio: physiological significance and clinical implications. Respir Physiol Neurobiol 2017: July 241: 17-22. Download
Borland C, Hughes JMB, Guénard H. The blood transfer conductance for CO and NO. Respir Physiol Neurobiol 2017 July 241: 53-57. Download
Hughes JMB. Diffusing capacity for nitric oxide (DLNO): is NO blood conductance (ΘNO) finite or infinite? Invited editorial on "Lung membrane conductance and capillary volume derived from the NO and CO transfer in high altitude newcomers". J Appl Physiol 2013; 115: 153–154. Download
Hughes JMB, van der Lee I. The TL,NO/TL,CO ratio in pulmonary function test interpretation. Review. Eur Respir J 2013 41: 453–461. Download
Transfer Factor/diffusing capacity for carbon monoxide (TLCO/DLCO)
Book
Hughes JMB. Physiology and Practice of Pulmonary Function. Association for Respiratory Technology and Physiology [artp.org.uk] (publisher), 2009. reprinted 2011, Pp 123-147, 273-281.
Chapters, reviews, editorials
Hughes Mike. Editorial. The Roughton–Forster equation for pulmonary diffusion: how it happened. Eur Respir J 2022; 60: 2200789 [DOI: 10.1183/ 13993003.00789-2022]. Download
Hughes JMB, Borland CDR. The centenary of the transfer factor for carbon monoxide (TLCO). Marie Keogh's legacy. Thorax 2015; 70(4): 391-4. Download
Hughes JMB, Pride NB. Examination of the carbon monoxide diffusing capacity (DLCO) in relation to its KCO and VA components. Concise Clinical Review. Amer J Respir Crit Care Med 2012; 186: 132–139. Download
Hughes JMB, Pride NB. In defence of the carbon monoxide transfer coefficient KCO (TL/ VA). Point of view. Eur Respir J 2001; 17: 168-174. Download
Hughes JMB. Pulmonary gas exchange. In: Lung Function Testing. R Gosselink and H Stam eds. European Respiratory Monograph, Vol 10, 2005. pp. 106-126.
Hughes JMB. The single breath transfer factor (TL,CO) and the transfer coefficient (KCO): a window onto the pulmonary microcirculation. Clin Physiol & Func Im 2003; 23: 63-71. Download
Original articles
Hughes JMB, Bates DV. Historical review: the carbon monoxide diffusing capacity and its membrane (DM) and red cell (Θ Vc) components. Respir Physiol Neurobiol. 2003; 138: 115-142. Download
Ewan PW, Jones HA, Rhodes CG, Hughes JMB. Detection of intrapulmonary hemorrhage with carbon monoxide uptake Application in Goodpature's Syndrome. New Engl. J. Med. 1976; 295: 1391-1396. Download
Jones, Hazel A, Clark JC, Davies EE, Forster RE, Hughes JMB. Rate of uptake of carbon monoxide at different inspired concentrations in humans. J. Appl. Physical. 1982; 52: 109-113. Download
Pulmonary Circulation
Book
Hughes JMB, Morrell NW. Pulmonary Circulation: from Basic Mechanisms to Clinical Practice. Imperial College Press (Cardiopulmonary Medicine Series), 2001. Pp 356. Amazon
Chapters
Hughes JMB, Shovlin CL, Simonds AK. Pulmonary Disease and Cor Pulmonale. In: Heart Disease in Pregnancy. ed CM Oakley.BMJ Publishing Group, 2007 pp 180-200.
Hughes JMB. Pulmonary complications of heart disease. In: Textbook of Respiratory Medicine. 4th Edn. Mason RJ, Boushey HA, Murray JF, Nadel JA eds: Elsevier Saunders, 2005 pp. 2200-22.
Hughes JMB. Distribution of pulmonary blood flow. In: The Lung: Scientific Foundations. 2nd Edn Crystal RG, West JB, Barnes PJ, Weibel ER, eds. New York: Raven Press, 1997 pp. 1523-36.
Original articles
Puri S, Baker BL, Dutka DP, Oakley CM, Hughes JMB, Cleland JGF. Increased alveolar–capillary membrane resistance to gas transfer in congestive heart failure. Brit Heart J. 1994; 72: 140–144. Download
Puri S, Baker BL, Dutka DP, Oakley CM, Hughes JMB, Cleland JGF. Reduced alveolar-capillary diffusing capacity in chronic heart failure: Its pathophysiological relevance and relationship to exercise performance. Circulation 1995; 91: 2769-2774. Download
Zhao L., Hughes JMB, Winter RJD. Reversal of pulmonary vascular remodelling following hypoxic exposure: no effect of infusion of atrial natriuretic factor and neutral endopeptidase inhibitor. Cardiovasc Res 1994; 28: 519-523. Download
Zhao L, Crawley DE, Hughes JMB, Evans TW, Winter RJD. Endothelium-derived relaxing factor activity in the rat lung during hypoxic pulmonary vascular remodelling. J. Appl Physiol 1993; 74: 1061-1065. Download
Winter RJD, Zhao L, Krausz T, Hughes JMB. Neutral endopeptidase inhibition reduces pulmonary vascular remodelling in rats exposed to chronic hypoxia. Amer Rev Resp Dis 1991; 144: 1342-1346 Download
Jones HA, Lakshminarayan S, Becket JM, Hughes JMB. Comparison of estimates of cardiac output by indicator dilution and freon-22 uptake during gas mixing in dogs. Cardiovasc Res 1991; 25: 523-528. Download
Glazier JB, Hughes JMB, Maloney JE, West JB. Measurements of capillary dimensions and blood volume in rapidly frozen lungs. J Appl Physiol 1969; 26: 65-76. Download
Hughes JMB, Glazier JB, Maloney JE, West JB. Effect of lung volume on the distribution of pulmonary blood flow in man.Respir Physiol 1968; 4: 58-72. Download
Gas Exchange
Editorial
Hughes Mike. Editorial. Novel gas exchange analysis in Covid–19 lung disease. Eur Respir J 2023; 61: 2201962 [DOI: 10.1183/13993003.01962-2022]. Download
Hughes JMB. Hypoxic pulmonary vasoconstriction: clinical implications. Eur Respir J. 2016 Jan; 47(1). 31-4. Download
Chapters, reviews
Hughes JMB. Gas Exchange. For: Pulmonary Circulation: Diseases and their Treatment (4th edition). A Peackock, R Naeije, L Rubin (eds). Taylor and Francis Group, LLC, publishers. Part 1, Chapter 3.
Hughes JMB. Pulmonary gas exchange. In: Lung Function Testing. R Gosselink and H Stam eds. European Respiratory Monograph, Vol 10, 2005. pp. 106-126.
Hughes JMB. Diffusive gas exchange. In: Exercise: Pulmonary Physiology and Pathophysiology (Lung Biology in Health and Disease Series Vol 52). Whipp BJ, Wassermann K, eds. Marcel Dekker Inc. 1991; 52: 143-171.
Original articles
Strickland NH, Hughes JMB, Hart DA, Myers MJ, Lavender JP. Cause of regional ventilation - perfusion mismatching in patients with idiopathic pulmonary fibrosis: a combined CT and scintigraphic study. Am J Roentgenol 1993; 161: 719-725. Download
Hempleman SC, Hughes JMB. Estimating DLO2 and diffusion limitation in patients with interstitial fibrosis. Respir Physiol 1991; 83: 167-178. Download
Hughes JMB, Lockwood DNA, Jones HA, Clark RJ. DLCO/Q and diffusion limitation at rest and on exercise in patients with interstitial fibrosis. Respir Physiol 1991; 83: 155-166. Download
Rhodes CG, Valind SO, Brudin LH, Wollmer PE, Jones T, Hughes JMB. Quantification of regional V/Q ratios in humans by the use of PET. I: theory. J Appl Physiol 1989; 66: 1896-1904. Download
Brudin LH, Valind SO, Rhodes CG, Turton DR, Hughes JMB. Regional lung hematocrit in humans using positron emission tomography. J Appl Physiol 1986; 60: 1155-1163. Download
Grant BJB, Davies EE, Jones HA, Hughes JMB. Local regulation of pulmonary blood flow and ventilation-perfusion ratios in the coati mundi. J Appl Physiol 1976; 40: 216-228. Download
Pulmonary Function
Books
Hughes JMB. Physiology and Practice of Pulmonary Function. Association for Respiratory Technology and Physiology (publishers). 2009 Pp 323.
Hughes JMB, Pride NB. Lung Function Tests: Physiological Principles and Clinical Applications. WB Saunders, Harcourt Brace and Co Ltd, 1999. Pp 314. (reprinted, 2000)
Reviews
Hughes JMB. Pulmonary function: the basics. Medicine 2008; 36: 142-150.
Hughes JMB. Pulmonary function. In: Radiology on CD–ROM. Taveras JM, Ferrucci JT, eds. Vol 1. Lippincott Williams Wilkins, 2002. (revised for 2003 edition).
Original articles
Schwarer AP, Hughes JMB, Trotman-Dickenson B, Krausz T, Goldman JM. A chronic pulmonary syndrome associated with graft versus host disease after allogeneic marrow transplantation. Transplantation 1992; 54: 1002-1008. Download
Brudin LH, Rhodes CG, Valind SO, Buckingham PD, Jones T, Hughes JMB. Regional structure-function correlations in chronic obstructive pulmonary lung disease measured with positron emission tomography. Thorax 1992; 47: 914-921. Download
Trotman-Dickenson B, Weetman AP, Hughes JMB. Upper airway obstruction and pulmonary function in acromegaly: relationship to disease activity. Quart J Med 1991; 79: 527-538. Download
Sutedja TG, Apperley JF, Hughes JMB, Aber VR, Kennedy HG, Nunn P, Hopper L, Goldman JM. Pulmonary function after bone marrow transplantation for chronic myeloid leukaemia. Thorax 1988 43: 163-169. Download
Greening AP, Hughes JMB. Serial estimations of carbon monoxide diffusing capacity in intrapulmonary haemorrhage. Clin Sci 1981 60: 507-512. Download
Ewan PW, Jones HA, Rhodes CG, Hughes JMB. Detection of intrapulmonary haemorrhage with carbon monoxide uptake: application in Goodpasture’s Syndrome. N Engl J Med 1976; 295:1391-1396. Download
Radionuclides 1: positron emission tomography (PET)
Reviews
Hughes JMB. 18F-fluorodeoxyglucose PET scans in lung cancer. Thorax 1996; 51: (Suppl 2): S16-22. DownloadRhodes CG, Hughes JMB. Pulmonary studies using positron emission tomography. Eur Respir J 1995; 8: 1001-17. Download
Original articles
Qing F, Rahman SU, Hayes M, Rhodes CG, Ind PW, Jones T, Hughes JMB. Effect of long-term beta2-agonist dosing on human cardiac beta-expression in vivo: Comparison with changes in lung and mononuclear leukocyte beta-receptors. J Nucl Cardiol 1997; 4: 532-538. Download
Qing F, Rahman SU, Rhodes CG, Hayes MJ, Sriskandan S, Ind PW, Jones T, Hughes JMB. Pulmonary and cardiac beta-adrenoceptor density in vivo in asthmatic subjects. Am J Resp Crit Care Med 1997; 155: 1130-34. Download
Hayes, MJ, Qing F, Rhodes CG, Rahman SU, Ind PW, Sriskandan S, Jones T, Hughes JMB.In vivo quantification of human pulmonary beta-adrenoceptors with PET: effect of beta-agonist therapy. Am J Resp Crit Care Med 1996; 154: 1277-1283. Download
Qing F, Rhodes CG, Hayes M, Krausz T, Fountain SW, Jones T, Hughes JMB.In vivo quantificaton of human pulmonary beta-adrenoceptor density using PET: comparison with in vitro radioligand binding. J Nucl Med 1996; 37: 1275-1281. Download
Brudin LH, Rhodes CG, Valind SO, Jones T, Hughes JMB. Interrelationships between regional blood flow, blood volume and ventilation in supine humans. J Appl Physiol 1994; 76: 1205-1210. Download
Brudin LH, Rhodes CG, Valind SO, Jones T, Jonson B. Hughes JMB. Relationships between regional ventilation and vascular and extravascular volume in supine humans. J Appl Physiol 1994; 76: 1195-1204. Download
Ueki J, Rhodes CG, Hughes JMB, Qing F, Brady F, Luthra SK, Steel CJ, Waters SL, Lammertsma AA, Camici PG, Jones T.In vivo quantification of pulmonary beta-adrenoceptor density in man using (S)-[11C]CGP-12177 and positron emission tomography. J Appl. Physiol 1993; 75: 559-565. Download
Brudin LH, Rhodes CG, Valind SO, Buckingham PD, Jones T, Hughes JMB. Regional structure-function correlations in chronic obstructive pulmonary lung disease measured with positron emission tomography. Thorax 1992; 47: 914-921. Download
Rhodes CG, Valind SO, Brudin LH, Wollmer PE, Jones T, Hughes JMB. Quantification of regional V/Q ratios in humans by the use of PET. I: theory. J Appl Physiol 1989; 66: 1896-1904. Download
Nolop KB, Rhodes CG, Brudin LH, Beaney RP, Krausz T, Jones T, Hughes JMB. Glucose utilization in vivo by human pulmonary neoplasms. Cancer 1987; 60: 2682-2689 Download
Brudin LH, Rhodes CG, Valind SO, Wollmer P, Hughes JMB. Regional lung density and blood volume in non- smoking and smoking subjects measured by PET. J Appl Physiol 1987; 63: 1324-1334. Download
Brudin LH, Valind SO, Rhodes CG, Turton DR, Hughes JMB. Regional lung hematocrit in humans using positron emission tomography. J Appl Physiol 1986; 60: 1155-1163. Download
Ewan PW, Jones HA, Rhodes CG, Hughes JMB. Detection of intrapulmonary haemorrhage with carbon monoxide uptake: application in Goodpasture’s Syndrome. N Engl J Med 1976; 295:1391-1396. Download
Radionuclides 2: gamma ray scintigraphy
Reviews
Hughes JMB. Role of gallium scanning in the management of chronic lung disease. In: Nuclear Medicine in Radiological Diagnosis. AM Peters,ed.Martin Dunitz, 2003. pp. 605-616.
Hughes JMB. Fleischner Lecture. Radionuclides and the Lung. Amer J. Roentgenol 1990; 155: 455-463. Download
Original articles
Thompson RJ, Jackson JE, Peters AM, Dore CJ, Hughes JMB. Sensitivity and specificity of radioisotope right to left shunt measurements and pulse oximetry for the early detection of pulmonary arteriovenous malformations. Chest 1999; 115: 109-113. Download
Whyte MKB, Hughes JMB, Peters AM, Ussov W, Patel S, Burroughs AK. Analysis of intrapulmonary right to left shunt in the hepatopulmonary syndrome. J Hepatol 1998; 29: 85-93. Download
Mason GR, Peters AM, Myers MJ, Hughes JMB. Appropriate background correction for DTPA aerosol clearance. J Appl Physiol 1997; 84: 1103-1107. Download
Whyte MKB, Hughes JMB, Jackson JE, Peters AM, Hempleman SC, Jones HA. Cardiopulmonary response to exercise in patients with intrapulmonary vascular shunts. J Appl Physiol 1993; 75: 321-328. Download
Whyte MKB, Peters AM, Hughes JMB, Henderson BL, Bellingan GJ, Jackson JE, Chilvers ER. Quantification of right-to-left shunt at rest and during exercise in patients with pulmonary arteriovenous malformations. Thorax 1992; 47: 790-796. Download
Chilvers ER, Whyte MKB, Jackson JE, Allison DJ, Hughes JMB. Effect of percutaneous transcatheter embolization on pulmonary function, right-to-left shunt, and arterial oxygenation in patients with pulmonary arteriovenous malformations. Am Rev Respir Dis 1990; 142: 420-425. Download
Wiener CM, Mckenna WJ, Myers MJ, Lavender JP, Hughes JMB. Left lower lobe ventilation is reduced in patients with cardiomegaly in the supine but not the prone position. Am Rev Respir Dis 1990; 141: 150-5. Download
Nolop KB, Maxwell DL, Fleming JS, Braude S, Hughes JMB, Royston D. A comparison of 99mTc-DTPA and 113mIn-DTPA aerosol clearances in humans. Effects of smoking, hyperinflation and in vitro oxidation. Am Rev Respir Dis 1987; 136:1112-1116. Download
Amis TC, Jones HA, Hughes JMB. Effect of posture on interregional distribution of pulmonary ventilation in man. Respir Physiol 1984; 56: 145-167. Download
Ciafetta G, Pratt TA, Hughes JMB. Regional pulmonary perfusion assess with continuous intravenous infusion of 81Krm; a comparison with 99Tcm-HAM.J Nucl Med 1978; 19: 1126-30. Download
Radionuclides 3: granulocyte studies, lung injury
Original articles
Mason GR, Peters AM, Bagdades E, Myers MJ, Snook D, Hughes JMB. Evaluation of pulmonary alveolar epithelial integrity by the detection of restriction to diffusion of hydrophilic solutes of different molecular sizes. Clin Sci 2001; 100: 231-6. Download
Ussov WY, Peters AM, Chapman PT, Ttofi A, Mason JC, Haskard DO, Hughes JMB. Pulmonary granulocyte kinetics in relation to endothelial and granulocyte activation. Clin Sci 1999; 96: 525-31. Download
Phillips M, Gleeson K, Hughes JMB, Greenberg J, Cataneo RN, Baker L, Mcvay WP. Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study. Lancet 1999; 353: 1930-3. Download
Ussov WY, Peters AM, Savill J, Pusey CD, Gaskin G, Hodgson HJH, Goldman JM, Hughes JMB. Relationships between granulocyte activation, pulmonary granulocyte kinetics and alveolocapillary barrier integrity in extrapulmonary inflammatory disease. Clinical Science 1996; 91: 329-335. Download
Mason GR, Peters AM, Myers MJ, Ind PW, Hughes JMB. The effect of inhalation of platelet activating factor on the pulmonary clearance of Tc-99m DTPA aerosol. Am J Resp Crit Care Med 1995; 151: 1621-1624. Download
Ussov WY, Peters AM, Glass DM, Gunasekera RD, Hughes JMB. Measurement of the pulmonary vascular granulocyte pool. J Appl Physiol 1995; 78: 1388-1395. Download
Ussov WY, Peters AM, Hodgson HJF, Hughes JMB. Quantification of pulmonary uptake of indium-111 labelled granulocytes in inflammatory bowel disease. Eur J Nucl Med 1994; 21: 6-11. Download
Braude S, Nolop KB, Hughes JMB, Barnes PJ, Royston D. Comparison of lung vascular and epithelial permeability indices in the Adult Respiratory Distress Syndrome. Am Rev Respir Dis 1986; 133: 1002-5. Download
Intrapulmonary shunting and haemorrhage
Reviews
Shovlin CL, Jackson JE, Hughes JMB. Pulmonary arteriovenous malformations and other pulmonary vascular abnormalities. In: Textbook of Respiratory Medicine Mason RJ, Boushey HA, Murray JF, Nadel JA eds: Elsevier Saunders. 4th Edn. 2005 pp. 1480-1501.
Hughes JMB. Pulmonary Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. In: Special issue on Pulmonary Vasculitis. ed RN duBois. Seminars in Respiratory and Critical Care Medicine 1997; 19: 79-89..
Hughes JMB. Intrapulmonary shunts: coils to transplantation (College lecture). J.Roy.Coll.Phys 1994; 28: 247-253
Original articles
Rizvi A, Macedo P, Babawale L, Tighe HC, Hughes JMB, Jackson JE, Shovlin CL. Hemoglobin Is a vital determinant of arterial oxygen content in hypoxemic patients with pulmonary arteriovenous malformations. Ann Am Thoracic Soc. 2017 Jun: 14(6); 903-911 Download
Howard LS, Santhirapala V, Murphy K, Mukherjee B, Busbridge M, Tighe HC, Jackson JE, Hughes JMB, Shovlin CL. Cardiopulmonary exercise testing demonstrates maintenance of exercise capacity in patients with hypoxemia and pulmonary arteriovenous malformations. Chest. 2014 Sep; 146(3): 709-18. doi: 10.1378/chest.13-2988. Download
Gupta P, Mordin C, Hughes JM, Shovlin CL, Jackson JE. Pulmonary arteriovenous malformations: effect of embolization on right-to-left shunt, hypoxemia, and exercise tolerance in 66 patients. Am J Roentgenol 2002; 179: 347-55. Download
Thompson RJ, Jackson JE, Peters AM, Dore CJ, Hughes JMB. Sensitivity and specificity of radioisotope right to left shunt measurements and pulse oximetry for the early detection of pulmonary arteriovenous malformations. Chest 1999; 115: 109-113. Download
Whyte MKB, Hughes JMB, Peters AM, Ussov W, Patel S, Burroughs AK. Analysis of intrapulmonary right to left shunt in the hepatopulmonary syndrome. J Hepatol 1998; 29: 85-93. Download
Shovlin CL, Hughes JMB, Scott J, Seidman CE, Seidman JG. Characterization of endoglin and identification of novel mutations in hereditary haemorrhagic telangiectasia. Am J Hum Genet 1997; 61: 68-79. Download
Dutton J, Jackson JE, Peters AM, Ueki J, Ussov W, Hughes JMB. Pulmonary arteriovenous malformations: pathophysiology and treatment with coil embolization. Am J Roentgenol 1995; 165: 1119-1125. Download
Shovlin CL, Winstock AR, Jackson JE, Peters AM, Hughes JMB. Medical complications of pregnancy in hereditary haemorrhagic telengiectasia . Quart J Med 1995; 88: 879-887. Download
Shovlin CL, Hughes JMB, Tuddenham EGD, Temperley I, Perembelon YFN, Scott J, Siedman CE, Seidman JG. A gene for hereditary haemorrhagic telangiectasia maps to chromosome 9q3. Nature Genetics 1994; 6:205-208. Download
Whyte MKB, Hughes JMB, Jackson JE, Peters AM, Hempleman SC, Jones HA. Cardiopulmonary response to exercise in patients with intrapulmonary vascular shunts. J Appl Physiol 1993; 75: 321-328. Download
Whyte MKB, Peters AM, Hughes JMB, Henderson BL, Bellingan GJ, Jackson JE, Chilvers ER. Quantification of right-to-left shunt at rest and during exercise in patients with pulmonary arteriovenous malformations. Thorax 1992; 47: 790-796. Download
Chilvers ER, Whyte MKB, Jackson JE, Allison DJ, Hughes JMB. Effect of percutaneous transcatheter embolization on pulmonary function, right-to-left shunt, and arterial oxygenation in patients with pulmonary arteriovenous malformations. Am Rev Respir Dis 1990; 142: 420-425. Download
Ewan PW, Jones HA, Rhodes CG, Hughes JMB. Detection of intrapulmonary haemorrhage with carbon monoxide uptake: application in Goodpasture’s Syndrome. N Engl J Med 1976; 295:1391-1396. Download
Respiratory physiology
Reviews
Hughes M (JMB), West JB. Point–Counterpoint: Gravity is/is not the major factor determining the distribution of blood flow in the human lung. J Appl Physiol 2008; 104: 1531-1540. Download
Original articles
Maxwell DL, Hughes JMB, Nye PCG. Effect of almitrine bimesylate on the steady-state responses of arterial chemoreceptors to CO2 and O2 in the cat. Respir Physiol 1988; 74: 275-284. Download
Maxwell DL, Chahal P, Nolop KB, Hughes JMB. Somatostatin inhibits the ventilatory response to hypoxia in humans. J Appl Physiol 1986; 60: 997-1002. Download
Jones HA, Davies EE, Hughes JMB. Modification of pulmonary gas mixing by postural changes. J Appl Physiol 1986; 61: 75-80. Download
Maxwell DL, Cover D, Hughes JMB. Effect of respiratory apparatus on timing and depth of breathing in man. Respir Physiol 1985; 61: 255-264. Download
Mannix SE, Bye P, Hughes JMB, Cover D, Davies EE. Effect of posture on ventilatory response to steady-state hypoxia and hypercapnia. Respir Physiol 1984; 58: 87-100. Download
Jones HA, Chakrabarti MK, Davies EE, Hughes JMB, Sykes MK. Contribution of heart beat to gas mixing in the lungs of dogs. Respir Physiol 1982; 50: 177-185. Download
Ewan PW, Jones HA, Nosil J, Obdrzalek J, Hughes JMB. Uneven perfusion and ventilation within lung regions studied with nitrogen-13. Respir Physiol 1978; 34:45-60. Download
Hughes JMB, Jones HA, Wilson AG, Grant BJB , Pride NB. Stability of intrapulmonary bronchial dimensions during expiratory flow in excised lungs. J Appl Physiol 1974; 37: 684-694. Download
Hughes JMB, Hoppin FG, Jnr., Mead J. Effect of lung inflation on bronchial length and diameter in excised lungs. J Appl Physiol 1972; 32: 25-35. Download
Hughes JMB, Rosenzweig DY. Factors affecting trapped gas volume in perfused dog lungs. J Appl Physiol 1970; 29: 332-9. Download
Hughes JMB, Rosenzweig DY, Kivitz PB. Site of airway closure in excised dog lungs: histological demonstration. J Appl Physiol 1970; 29: 340-4. Download
Glazier JB, Hughes JMB, Maloney JE, West JB. Measurements of capillary dimensions and blood volume in rapidly frozen lungs. J Appl Physiol 1969; 26: 65-76. Download
Hughes JMB, Glazier JB, Maloney JE, West JB. Effect of extra-alveolar vessels on distribution of blood flow in dog lung.J Appl Physiol 1968;25: 701-12. Download
Hughes JMB, Glazier JB, Maloney JE, West JB. Effect of lung volume on the distribution of pulmonary blood flow in man.Respir Physiol 1968; 4: 58-72. Download
Glazier JB, Hughes JMB, Maloney JE, West JB. Vertical gradient of alveolar size in lungs of dogs frozen intact. J Appl Physiol 1967; 23: 694-705. Download
Hughes JMB Central respiratory failure reversed by treatment. Brainl 1967; 90:675-680. Download